U.S. companies face mounting demands to examine their supply chains to comply with increasingly complex sanctions and trade controls, particularly targeting China and Russia. Businesses cannot relax just because they have conducted due diligence on one or two tiers of partners or are not active in an especially scrutinized sector. This article addresses strategic approaches that businesses can take to ensure they are on the right compliance track and show regulators they are making good-faith efforts. It distills insights offered during a presentation hosted by data analytics company Kharon, featuring its own officers, a Miller & Chevalier attorney, and Resilinc's president for government and defense. See “Navigating the ‘Uncharted Waters’ of Global Supply-Chain Risks” (Dec. 7, 2022).